MTHFR
Description
MTHFR (methylenetetrahydrofolate reductase) is a key enzyme in the body’s methylation process, which affects how we detoxify, build neurotransmitters, produce energy, and metabolize hormones. Genetic variants in MTHFR (such as C677T or A1298C) may reduce enzyme efficiency, especially when combined with nutrient deficiencies, stress, toxins, or other SNPs affecting the methylation cycle. Functional medicine evaluates not just genetics but functional biomarkers—like homocysteine, B12, and folate—to determine how well your methylation pathways are working. Targeted support can help improve mood, detoxification, cardiovascular resilience, and overall vitality.
Symptoms
Fatigue or low energy
Anxiety or depression
Brain fog or poor focus
Hormone imbalances
Elevated homocysteine
Poor detox or sensitivity to smells
Frequent miscarriages or fertility issues
Inflammation or cardiovascular risk
Sensitivity to supplements or medications
Chronic illness without clear cause
Labs & Testing Options
MTHFR gene testing (saliva or blood)
Homocysteine
Serum and intracellular B12, folate, and B6
Methylmalonic acid (MMA)
Organic acids test
Vitamin D and magnesium levels
Glutathione status
Heavy metals and toxin panels
Histamine and DAO activity (if relevant)
Treatment Options
Methylated B vitamins (methyl-B12, methylfolate, P-5-P)
Magnesium, zinc, and vitamin C support
Glutathione or NAC for detox and antioxidant defense
Dietary folate (dark leafy greens, legumes) vs. folic acid avoidance
Avoiding synthetic additives or preservatives
Stress management and circadian alignment
Binder and drainage support (if impaired detox)
Gradual titration of supplements (some are sensitive)
Mood swings, fatigue, detox struggles? Methylation matters—get tested and supported with the right nutrients.