MTHFR (methylenetetrahydrofolate reductase) is a key enzyme in the body’s methylation process, which affects how we detoxify, build neurotransmitters, produce energy, and metabolize hormones. Genetic variants in MTHFR (such as C677T or A1298C) may reduce enzyme efficiency, especially when combined with nutrient deficiencies, stress, toxins, or other SNPs affecting the methylation cycle. Functional medicine evaluates not just genetics but functional biomarkers—like homocysteine, B12, and folate—to determine how well your methylation pathways are working. Targeted support can help improve mood, detoxification, cardiovascular resilience, and overall vitality.