What Is Ozone or Prolozone Injection Therapy?

Q: What is Ozone therapy?

Ozone injections are a regenerative approach pioneered in the 1990s. Derived from “proliferation” and “ozone,” it combines principles of prolotherapy, neural therapy, and medical‑grade ozone/O₂ gas, often alongside vitamins, minerals, procaine, and homeopathics, delivered directly into injured connective tissues or joints.

Q: How does ozone function in this therapy?

In nature, oxygen is most stable as O₂, which is 2 oxygen molecules paired together. Ozone (O₃) is an unstable oxygen molecule that readily gives off the 3rd oxygen atom. When the ozone gas is injected into the body, the extra oxygen is donated to the surrounding tissue, which increases oxygenation and stimulates cellular repair, enhanced circulation, reduced inflammation, growth factor/collagen stimulation, and improved energy production support healing.

Ozone Injection Therapy Sessions

Q: What are the components and steps of a Prolozone session?

Typical treatment includes:

1. Local anesthetic (e.g. procaine) + mild anti-inflammatory

2. Injection of vitamins, minerals, dextrose or homeopathics to prime healing

3. Administration of ozone/O₂ gas into the targeted tissueSometimes therapeutic ultrasound or low-level laser may be added.

Q: Why does Prolozone cause healing?

Each component plays a role: procaine repolarizes cell membranes; nutrients support metabolism; ozone boosts oxygenation and antioxidants; together, this interrupts pain cycles while promoting collagen synthesis, tissue regeneration, and improved mobility.

What Conditions Can Ozone Treat?

Q: What kinds of pain or injuries is it used for?

Clinically, Prolozone is used for a wide range of musculoskeletal issues, such as:

• Degenerative spinal discs & chronic back or neck pain

• Osteoarthritis of knees, hips, shoulders

• Rotator cuff injuries, tendonitis, ligament strains

• Sciatica, carpal tunnel syndrome, plantar fasciitis

• TMJ, sports injuries, chronic trigger points or scar tissueSome providers have explored its use in sinus issues, dental infections, or diabetic neuropathy—but evidence is strongest for orthopedic use.

Benefits and Risks

Q: What benefits can people expect?

• Rapid onset pain relief—often within days of first session

• Reduced inflammation and improved mobility

• Regeneration of cartilage, ligaments, tissues

• Avoidance or postponement of surgery

• Low risk when performed by trained professionals

Clinical reports suggest up to ~75–85 % of chronic pain patients experience long‑term improvement.

Q: What are the potential side effects or risks?

Although generally well-tolerated, Prolozone can cause:

• Temporary soreness, bruising, minor inflammation at injection sites

• Rare risks related to improper injection technique, such as gas embolism or allergic reactions

• Severe adverse events are uncommon when administered properly—gas embolisms historically occurred with untrained misuse of direct gas injections.

  
  

Q: Is Prolozone FDA‑approved?

Prolozone remains classified as alternative medicine, with limited high‑quality clinical trials. Patients should discuss the benefits vs risks of their own conditions with a experienced healthcare provider.

Common Questions Patients Ask

Q: Are there any research studies on ozone safety & effectiveness?

1- "O2O3 intramuscular lumbar paravertebral injections, which are minimally invasive, seem to safely and effectively relieve pain, as well as reduce both disability and the intake of analgesic drugs."

2- "In 2 months follow up, significant improvement of pain, stiffness, and function were seen in all groups compared to the baseline, but the ozone group had the best results"

3- "This study demonstrates that intra-articular ozone (O₂-O₃) injection resulted in significant clinical improvements in pain, function, and range of motion in patients with primary adhesive capsulitis."

Q: How many treatments are needed and what’s the timeline? Some patients notice improvement after just one injection. Others require multiple sessions spaced weeks apart (often 3–5 total). Maintenance sessions may follow depending on condition and progress.

Q: Does it hurt?

A mild sting or fullness at the injection site is normal. Some soreness or swelling may persist for a day or two, typically resolving quickly. Practitioners often pre‑inject a local anesthetic to minimize discomfort.

Q: Who is a good candidate for Prolozone?

Ideal for adults experiencing chronic joint or soft‑tissue pain, seeking non‑surgical and drug‑free relief. Not advised for those allergic to any injection components, or with contraindications like severe bleeding disorders or infection at the injection site. Evaluation by a licensed practitioner is essential.

How It Fits at Harmony Health Clinic in Naples, FL

Prolozone injection therapy aligns with our holistic wellness approach at Harmony Health Clinic in Naples, offering an integrative, non‑surgical treatment option for adults and retirees experiencing joint, back, or soft‑tissue pain. We evaluate each patient individually to determine if Prolozone complements our other services like chiropractic care, functional medicine, telemedicine, or weight‑loss.

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Disclaimer: This article is for informational purposes only and does not constitute medical advice. Always consult with a licensed healthcare professional.